Česky
A report on this remarkable procedure was published earlier this month in the online periodical The Lancet, and Mats Brännström, a physician and professor in both gynaecology and obstetrics in Gothenburg, Sweden, and his colleagues described what the care of this patient was like.
Uterine transplantation is used for women who either have no uterus at all or their uterus is non-functional. So far, it has only been performed on 11 patients worldwide, but to date none of these women have given birth to a live child.
The patient in question was born with congenital absence of the uterus, also known as Rokitansky syndrome. She then underwent a uterus transplant as an adult, the donor being a healthy menopausal woman who had previously given birth to two children. The patient and her partner then underwent in vitro fertilisation before the transplantation itself, during which a total of 11 embryos were cryopreserved. The operation itself went well, as did the post-operative period, and the patient had her first menstrual period 43 days after the procedure. Her menstrual cycle continued to be regular between 26-36 days.
One year after the transplant, she became pregnant on her first attempt, and had to take a triple combination of immunosuppressants (tacrolimus, azathioprine and corticosteroids) throughout the pregnancy. During the pregnancy she had one episode of mild rejection (two more, also mild, before becoming pregnant), but thanks to corticotherapy they were averted.
At 31 weeks of gestation, the patient was admitted to hospital for pre-eclampsia with abnormal fetal cardiac monitoring and therefore a caesarean section was performed 16 hours later. The newborn boy weighed 1775g and his Apgar score was 9-9-10 and he was discharged from the hospital on the tenth day after birth in good general condition.
Source. Published online October 6, 2014.
